What happens if acetylcholinesterase is inhibited

What happens if acetylcholinesterase is inhibited

It had been assumed that genetic variants of acetylcholinesterase were incompatible with life and therefore were not present in living humans.Irreversible acetylcholinesterase inhibitors phosphorylate the acetylcholinesterase enzyme permanently [1], causing acetylcholine to build up to toxic levels in the nervous system.This could cause unwanted and prolonged muscle.Acetylcholine will lose specificity of the response.What happens if acetylcholinesterase is inhibited (blocked)?

They lead to a cholinergic crisis involving paralysis and death by asphyxiation, as the afflicted are not able to control muscles involved in breathing.If acetylcholinesterase activity is inhibited, the synaptic concentration of acetylcholine will remain higher than normal.Acetylcholine will be prematurely terminated.In general, cholinesterase inhibitors induced bradycardia by preventing the hydrolysis of ach released from parasympathetic neurons and following stimulation of cardiac m 2 receptors.If acetylcholinesterase activity is inhibited, the synaptic concentration of acetylcholine will remain higher than normal.

Cholinesterase, or, more properly, acetylcholinesterase, is an enzyme essential for normal functioning of the nervous system of humans, other vertebrates, birds, and insects.

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